Name: Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-Fc)
SKU: FABVC-176
Rating: 5 (1 reviews)

Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-IL17A antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-IL17F to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block two proinﬂammatory cytokines simultaneously. It is designed for the research of Multiple sclerosis (MS); Autoimmune diseases; Inflammatory diseases therapy.

Datasheet INQUIRY

Specifications

Targets

IL17A & IL17F

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Multiple sclerosis (MS); Autoimmune diseases; Inflammatory diseases

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

IL17A

Gene ID

3605

UniProt ID

Q16552

Alternative Names

IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Target 2

IL17F

Gene ID

112744

UniProt ID

Q96PD4

Alternative Names

IL17; Interleukin 17; IL17F; Interleukin 17F; ML1; ML-1; CANDF6; IL-17F; cytokine ML-1

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-176)

Specifications

Targets

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