Home > Products > IL23 & IL6 > Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-178)

Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-IL23 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-IL6 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block two proinflammatory cytokines simultaneously. It is designed for the research of Inflammatory diseases therapy.

Specifications

Targets
IL23 & IL6
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
IL23
Host Animal 1
Mouse
Target 2
IL6
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Inflammatory diseases

Targets

Target 1
IL23
Gene ID
UniProt ID
Alternative Names
P19; SGRF; IL-23; IL-23A; IL23P19; Interleukin-23; IL23; interleukin 23 subunit alpha
Target 2
IL6
Gene ID
UniProt ID
Alternative Names
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2; interleukin 6; IL6

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