Home > Products > IL23 & IL6 > Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc-scFv)

Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc-scFv)  (BSTF-H343)

Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-IL23 scFv is fused to the N-terminus of Fc via a hinge region while another anti-IL6 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can block two proinflammatory cytokines simultaneously. It is designed for the research of Inflammatory diseases therapy.

Specifications

Targets
IL23 & IL6
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
IL23
Host Animal 1
Mouse
Target 2
IL6
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Inflammatory diseases

Targets

Target 1
IL23
Gene ID
UniProt ID
Alternative Names
P19; SGRF; IL-23; IL-23A; IL23P19; Interleukin-23; IL23; interleukin 23 subunit alpha
Target 2
IL6
Gene ID
UniProt ID
Alternative Names
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2; interleukin 6; IL6

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