Home > Products > Kit & VCAM-1 > Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Diabody-CH3)

Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Diabody-CH3)  (BSDBC-H344)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-Kit and anti-VCAM-1 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.

Specifications
Targets
Kit & VCAM-1
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
Kit
Host Animal 1
Human
Target 2
VCAM-1
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Cardiovascular disease
Targets
Target 1
Kit
Gene ID
UniProt ID
Alternative Names
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3; KIT proto-oncogene receptor tyrosine kinase; KIT
Target 2
VCAM-1
Gene ID
UniProt ID
Alternative Names
CD106, INCAM-100; Vascular cell adhesion molecule-1; VCAM-1; vascular cell adhesion protein 1
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