Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-Kit IgG with similar domains from an anti-VCAM-1 antibody via short peptide linkers, or vice versa. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.
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