Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Minibody) (MiniB-179)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Minibody) is designed to be expressed as the anti-Kit scFv fused to N-terminus of Knob-CH3 domain and the anti-VCAM-1 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.

Datasheet

Specifications

Targets

Kit & VCAM-1

Type

Minibody

Species Reactivity

Human

Target 1

Kit

Host Animal 1

Mouse

Target 2

VCAM-1

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Cardiovascular disease

Targets

Target 1

Kit

Gene ID

3815

UniProt ID

A0A024RDA0

Alternative Names

W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3; KIT proto-oncogene receptor tyrosine kinase; KIT

Target 2

VCAM-1

Gene ID

7412

UniProt ID

P19320

Alternative Names

CD106, INCAM-100; Vascular cell adhesion molecule-1; VCAM-1; vascular cell adhesion protein 1

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