Home > Products > Kit & VCAM-1 > Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-CH3)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-CH3)  (BSFC-H344)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-CH3) contains two chains. The anti-Kit scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-VCAM-1 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.

Specifications
Targets
Kit & VCAM-1
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
Kit
Host Animal 1
Mouse
Target 2
VCAM-1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cardiovascular disease
Targets
Target 1
Kit
Gene ID
UniProt ID
Alternative Names
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3; KIT proto-oncogene receptor tyrosine kinase; KIT
Target 2
VCAM-1
Gene ID
UniProt ID
Alternative Names
CD106, INCAM-100; Vascular cell adhesion molecule-1; VCAM-1; vascular cell adhesion protein 1

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