Home > Products > Kit & VCAM-1 > Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-Fc-scFv)  (BSTF-179)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-Kit scFv is fused to the N-terminus of Fc via a hinge region while another anti-VCAM-1 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.

Specifications
Targets
Kit & VCAM-1
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
Kit
Host Animal 1
Mouse
Target 2
VCAM-1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cardiovascular disease
Targets
Target 1
Kit
Gene ID
UniProt ID
Alternative Names
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3; KIT proto-oncogene receptor tyrosine kinase; KIT
Target 2
VCAM-1
Gene ID
UniProt ID
Alternative Names
CD106, INCAM-100; Vascular cell adhesion molecule-1; VCAM-1; vascular cell adhesion protein 1
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