Home > Products > Kit & VCAM-1 > Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv4-Ig)

Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv4-Ig)  (FVTIG-H344)

Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-Kit scFv is fused to the CH1 domain of a heavy chain and another anti-VCAM-1 scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget hematopoietic stem cells toinjured myocardium. It is designed for the research of Cardiovascular disease therapy.

Specifications

Targets
Kit & VCAM-1
Type
Appended IgGs
Species Reactivity
Human
Target 1
Kit
Host Animal 1
Human
Target 2
VCAM-1
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Cardiovascular disease

Targets

Target 1
Kit
Gene ID
UniProt ID
Alternative Names
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3; KIT proto-oncogene receptor tyrosine kinase; KIT
Target 2
VCAM-1
Gene ID
UniProt ID
Alternative Names
CD106, INCAM-100; Vascular cell adhesion molecule-1; VCAM-1; vascular cell adhesion protein 1

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