Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-malaria antigen antibody variable domain is fused to CH1 and the other scFv from an anti-TLR1 antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can retarget professional antigen-presenting cells (APCs) including DCs or NK cells to malaria antigen. It is designed for the research of Malaria therapy.
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