Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) (BABFV-182)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-NGF specificity is fused to the C terminus of the anti-TNF Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

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Specifications

Targets

NGF & TNF

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-182)

Specifications

Targets

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