Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-scFv-Fc) (FABVC-H346)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-NGF antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-TNF to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

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Specifications

Targets

NGF & TNF

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-H346)

Specifications

Targets

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