Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) (BSCFV-182)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-NGF specificity or anti-TNF specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

Datasheet INQUIRY

Specifications

Targets

NGF & TNF

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) (CAT#: BSCFV-182)

Specifications

Targets

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