Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) (BSTF-H346)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-NGF scFv is fused to the N-terminus of Fc via a hinge region while another anti-TNF scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

Datasheet INQUIRY

Specifications

Targets

NGF & TNF

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-H346)

Specifications

Targets

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