Name: Recombinant Human Anti-NkG2A x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0725-N17
Rating: 5 (1 reviews)

Recombinant Human Anti-NkG2A x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-NkG2A scFvs are fused to the C terminus of the anti-EGFR IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

NkG2A & EGFR

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors

Host Animal 1

Human

Host Animal 2

Mouse

Targets

Target 1

NkG2A

Gene ID

3821

UniProt ID

P26715

Alternative Names

Killer cell lectin-like receptor subfamily C member 1; KLRC1; CD159 antigen-like family member A; NKG2-A; NKG2-1; NK group 2 member A; KLR family member C1; NK cell inhibitory receptor for HLA-E; NKG2; NKG2A; CD159A; killer cell lectin like receptor C1; NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a

Target 2

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-NkG2A x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0725-N17)

Specifications

Targets

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