Name: Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0725-N1
Rating: 5 (1 reviews)

Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-Nkp46 scFvs are fused to the C terminus of the anti-CD30 IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL) therapy.

Datasheet INQUIRY

Specifications

Targets

Nkp46 & CD30

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL)

Host Animal 1

Human

Host Animal 2

Mouse

Targets

Target 1

Nkp46

Gene ID

9437

UniProt ID

O76036

Alternative Names

CD335; NCR1; Natural Cytotoxicity Triggering Receptor 1, gene symbol; NK-p46; Natural Killer Cell Activating Receptor p46; LY94; CD335; NKP46; NK-p46; Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NCR1

Target 2

CD30

Gene ID

943

UniProt ID

A5D8T4

Alternative Names

TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0725-N1)

Specifications

Targets

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