Name: Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0725-N5
Rating: 5 (1 reviews)

Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-Nkp46 scFvs are fused to the C terminus of the anti-EGFR IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

Nkp46 & EGFR

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors

Host Animal 1

Human

Host Animal 2

Mouse

Targets

Target 1

Nkp46

Gene ID

9437

UniProt ID

O76036

Alternative Names

CD335; NCR1; Natural Cytotoxicity Triggering Receptor 1, gene symbol; NK-p46; Natural Killer Cell Activating Receptor p46; LY94; CD335; NKP46; NK-p46; Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NCR1

Target 2

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0725-N5)

Specifications

Targets

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