Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) (FABVC-183)

Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-OPN antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGF to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind two factors simultaneously. It is designed for the research of Hepatocellular cancer; Metastatic cancer therapy.

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Specifications

Targets

OPN & VEGF

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hepatocellular cancer; Metastatic cancer

Targets

Target 1

OPN

Gene ID

6696

UniProt ID

A0A024RDE6

Alternative Names

OPN; BNSP; BSPI; ETA-1; Osteopontin; bone sialoprotein I; BSP-1; SPP1; secreted phosphoprotein 1

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-183)

Specifications

Targets

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