Recombinant Human Anti-OPN x Human Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) (BSTF-H347)

Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-OPN scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGF scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind two factors simultaneously. It is designed for the research of Hepatocellular cancer; Metastatic cancer therapy.

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Specifications

Targets

OPN & VEGF

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hepatocellular cancer; Metastatic cancer

Targets

Target 1

OPN

Gene ID

6696

UniProt ID

A0A024RDE6

Alternative Names

OPN; BNSP; BSPI; ETA-1; Osteopontin; bone sialoprotein I; BSP-1; SPP1; secreted phosphoprotein 1

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-OPN x Human Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-H347)

Specifications

Targets

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