Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-OPN scFv is fused to the CH1 domain of a heavy chain and another anti-VEGF scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously. It is designed for the research of Hepatocellular cancer; Metastatic cancer therapy.
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