Name: Recombinant Human Anti-PD-L1 x Human Anti-ICOS Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0825-N28
Rating: 5 (1 reviews)

Recombinant Human Anti-PD-L1 x Human Anti-ICOS Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-PD-L1 scFvs are fused to the C terminus of the anti-ICOS IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can block can block the PD-L1 signal and activate the ICOS signal, enhance T cell activation. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

PD-L1 & ICOS

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD-L1

Gene ID

29126

UniProt ID

Q9NZQ7

Alternative Names

Programmed Death-Ligand 1; CD274; B7-H1; Cluster of Differentiation 274; Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1; PDCD1L1, PDCD1LG1; B7-H; ADMIO5; hPD-L1

Target 2

ICOS

Gene ID

29851

UniProt ID

Q9Y6W8

Alternative Names

CD278; Inducible T-cell costimulator; ICOS; CD278 antigen; Activation-inducible lymphocyte immunomedatory molecule; AILIM; ICOS ligand receptor; H4; CVID1

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-PD-L1 x Human Anti-ICOS Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0825-N28)

Specifications

Targets

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