Name: Recombinan Human Anti-PD-L1 x Human Anti-VISTA Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N66
Rating: 5 (1 reviews)

Recombinan Human Anti-PD-L1 x Human Anti-VISTA Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PD-L1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VISTA to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block PD-L1 and VISTA signals, enhance T cell activation. It is designed for the research of pancreatic, endometrial and breast cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PD-L1 & VISTA

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic, Endometrial and Breast cancers

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD-L1

Gene ID

29126

UniProt ID

Q9NZQ7

Alternative Names

Programmed Death-Ligand 1; CD274; B7-H1; Cluster of Differentiation 274; Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1; PDCD1L1, PDCD1LG1; B7-H; ADMIO5; hPD-L1

Target 2

VISTA

Gene ID

64115

UniProt ID

Q9H7M9

Alternative Names

VISTA; V-domain Ig-containing Suppressor of T-cell Activation; B7-H5; B7 homolog 5; Gi24; SISP1; sialic acid-binding Ig-type lectin 11 pseudogene 1; Dieg1; differentiation gene 1 homolog; VSIR; V-set immunoregulatory receptor; B7H5; GI24; PD-1H; PP2135; C10orf54; DD1alpha; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; Stress-induced secreted protein-1; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; UNQ730/PRO1412

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-PD-L1 x Human Anti-VISTA Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N66)

Specifications

Targets

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