Name: Recombinan Human Anti-PD1 x Human Anti-HER2 Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N59
Rating: 5 (1 reviews)

Recombinant Human Anti-PD1 x Human Anti-HER2 Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PD1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-HER2 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block the PD1 signal and inhibit HER2-mediated proliferation. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

PD1 & HER2

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

HER2

Gene ID

2064

UniProt ID

P04626

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-PD1 x Human Anti-HER2 Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N59)

Specifications

Targets

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