Name: Recombinan Human Anti-PD1 x Human Anti-LAG3 Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N60
Rating: 5 (1 reviews)

Recombinant Human Anti-PD1 x Human Anti-LAG3 Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PD1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-LAG3 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block PD-L1 and LAG3 signals, enhance T cell activation. It is designed for the research of Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PD1 & LAG3

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

LAG3

Gene ID

3902

UniProt ID

P18627

Alternative Names

Lymphocyte activation gene 3 protein; LAG3; CD223; FDC; Protein FDC

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-PD1 x Human Anti-LAG3 Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N60)

Specifications

Targets

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