Name: Recombinan Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N61
Rating: 5 (1 reviews)

Recombinant Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PD1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-OX40 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block the PD1 signal and activate the OX40 signal, enhance T cell activation. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

PD1 & OX40

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

OX40

Gene ID

7293

UniProt ID

P43489

Alternative Names

TNFRSF4; CD134; ACT35; OX-40 receptor; Tumor necrosis factor receptor superfamily member 4; TNFRSF4 TNF receptor superfamily member 4; OX40; IMD16; TXGP1L; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N61)

Specifications

Targets

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