Name: Recombinan Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0825-N32
Rating: 5 (1 reviews)

Recombinant Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-PD1 scFvs are fused to the C terminus of the anti-OX40 IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can block the PD-L1 signal and activate the OX40 signal, enhance T cell activation. It is designed for the research of Solid tumors therapy.

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Specifications

Targets

PD1 & OX40

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

OX40

Gene ID

7293

UniProt ID

P43489

Alternative Names

TNFRSF4; CD134; ACT35; OX-40 receptor; Tumor necrosis factor receptor superfamily member 4; TNFRSF4 TNF receptor superfamily member 4; OX40; IMD16; TXGP1L; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinan Human Anti-PD1 x Human Anti-OX40 Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0825-N32)

Specifications

Targets

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