Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Diabody-CH3) (BSDBC-185)

Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-PD1 and anti-TIM-3 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two receptors simultaneously and target unresponsive immune cells. It is designed for the research of Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PD1 & TIM-3

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

TIM-3

Gene ID

84868

UniProt ID

Q8TDQ0

Alternative Names

TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; T cell immunoglobulin and mucin domain 3; HAVCR2; hepatitis A virus cellular receptor 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-185)

Specifications

Targets

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