Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (F(ab')2-scFv2) (BABFV-185)

Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-PD1 specificity is fused to the C terminus of the anti-TIM-3 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind two receptors simultaneously and target unresponsive immune cells. It is designed for the research of Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PD1 & TIM-3

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Targets

Target 1

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2

TIM-3

Gene ID

84868

UniProt ID

Q8TDQ0

Alternative Names

TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; T cell immunoglobulin and mucin domain 3; HAVCR2; hepatitis A virus cellular receptor 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-185)

Specifications

Targets

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