Home > Products > PDGFR1 & VEGF > Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody-CH3)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody-CH3)  (BSDBC-H349)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-PDGFR1 and anti-VEGF antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two antigens simultaneously. It is designed for the research of Neovascular ocular disorders; Cancers therapy.

Specifications
Targets
PDGFR1 & VEGF
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
PDGFR1
Host Animal 1
Human
Target 2
VEGF
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Neovascular ocular disorders; Cancers
Targets
Target 1
PDGFR1
Gene ID
UniProt ID
Alternative Names
IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRβ; platelet-derived growth factor receptor beta; PDGFRB
Target 2
VEGF
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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