Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) (BABFV-186)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-PDGFR1 specificity is fused to the C terminus of the anti-VEGF Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind two antigens simultaneously. It is designed for the research of Neovascular ocular disorders; Cancers therapy.

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Specifications

Targets

PDGFR1 & VEGF

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Neovascular ocular disorders; Cancers

Targets

Target 1

PDGFR1

Gene ID

5159

UniProt ID

P09619

Alternative Names

IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRβ; platelet-derived growth factor receptor beta; PDGFRB

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-186)

Specifications

Targets

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