Name: Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc)
SKU: FABVC-186
Rating: 5 (1 reviews)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PDGFR1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGF to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind two antigens simultaneously. It is designed for the research of Neovascular ocular disorders; Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PDGFR1 & VEGF

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Neovascular ocular disorders; Cancers

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

PDGFR1

Gene ID

5159

UniProt ID

P09619

Alternative Names

IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRβ; platelet-derived growth factor receptor beta; PDGFRB

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-186)

Specifications

Targets

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