Name: Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv)
SKU: BSTF-186
Rating: 5 (1 reviews)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-PDGFR1 scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGF scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind two antigens simultaneously. It is designed for the research of Neovascular ocular disorders; Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PDGFR1 & VEGF

Type

scFv-Fc-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Neovascular ocular disorders; Cancers

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

PDGFR1

Gene ID

5159

UniProt ID

P09619

Alternative Names

IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRβ; platelet-derived growth factor receptor beta; PDGFRB

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-186)

Specifications

Targets

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