Home > Products > PDGFR2 & VEGFR2 > Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody-Fc)

Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody-Fc)  (BSDBF-187)

Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-PDGFR2 and anti-VEGFR2 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can block two receptors simultaneously. It is designed for the research of Cancers therapy.

Specifications

Targets
PDGFR2 & VEGFR2
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
PDGFR2
Host Animal 1
Mouse
Target 2
VEGFR2
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers

Targets

Target 1
PDGFR2
Gene ID
UniProt ID
Alternative Names
PDGFRA; PDGFR2; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; PDGF alpha chain; CD140 antigen-like family member A; platelet-derived growth factor alpha receptor; alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
Target 2
VEGFR2
Gene ID
UniProt ID
Alternative Names
FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

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