Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Fab-scFv-Fc) (FABVC-H350)

Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-PDGFR2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGFR2 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block two receptors simultaneously. It is designed for the research of Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

PDGFR2 & VEGFR2

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Targets

Target 1

PDGFR2

Gene ID

5156

UniProt ID

P16234

Alternative Names

PDGFRA; PDGFR2; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; PDGF alpha chain; CD140 antigen-like family member A; platelet-derived growth factor alpha receptor; alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)

Target 2

VEGFR2

Gene ID

3791

UniProt ID

A0A024RD88

Alternative Names

FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-H350)

Specifications

Targets

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