Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-Fc-scFv) (BSTF-H350)

Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-PDGFR2 scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGFR2 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can block two receptors simultaneously. It is designed for the research of Cancers therapy.

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Specifications

Targets

PDGFR2 & VEGFR2

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Targets

Target 1

PDGFR2

Gene ID

5156

UniProt ID

P16234

Alternative Names

PDGFRA; PDGFR2; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; PDGF alpha chain; CD140 antigen-like family member A; platelet-derived growth factor alpha receptor; alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)

Target 2

VEGFR2

Gene ID

3791

UniProt ID

A0A024RD88

Alternative Names

FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-H350)

Specifications

Targets

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