Home > Products > CD3 & PSCA > Recombinant Human Anti-PSCA x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody)

Recombinant Human Anti-PSCA x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody)  (SCTB-H170)

Recombinant Anti-PSCA x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) is designed to be expressed as a single chain with three scFv units, two distal binding sites for PSCA and a central site for CD3. It contains a His-tag at the C/N terminus for affinity purification. This BsAb can retarget T cells to tumor cells. It is designed for the research of Prostate cancer therapy.

Specifications
Targets
CD3 & PSCA
Type
Single-chain Triplebody
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
PSCA
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Prostate cancer
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.
Target 2
PSCA
Gene ID
UniProt ID
Alternative Names
PSCA; prostate stem cell antigen; PRO232
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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