Home > Products > TG & TPO > Recombinant Human Anti-TG x Human Anti-TPO Bispecific Antibody (Diabody-CH3)

Recombinant Human Anti-TG x Human Anti-TPO Bispecific Antibody (Diabody-CH3)  (BSDBC-H351)

Recombinant Anti-TG x Anti-TPO Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-TG and anti-TPO antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two antigens simultaneously and block the synthesis of thyroid hormones. It is designed for the research of Autoimmune thyroid disease therapy.

Specifications

Targets
TG & TPO
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
TG
Host Animal 1
Human
Target 2
TPO
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Autoimmune thyroid disease

Targets

Target 1
TG
Gene ID
UniProt ID
Alternative Names
AITD3, TG; thyroglobulin; TGN
Target 2
TPO
Gene ID
UniProt ID
Alternative Names
MSA; TPX; TDH2A; TPPO; thrombopoietin; megakaryocyte growth and development factor; MGDF

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