Recombinant Anti-TG x Anti-TPO Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-TG IgG with similar domains from an anti-TPO antibody via short peptide linkers, or vice versa. This BsAb can bind two antigens simultaneously and block the synthesis of thyroid hormones. It is designed for the research of Autoimmune thyroid disease therapy.
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