Home > Products > TG & TPO > Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scDiabody-Fc)

Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scDiabody-Fc)  (SCDBF-189)

Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scDiabody-Fc) is a fusion protein of two scDiabodies with an Fc region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-TG/anti-TPO diabody. The scDiabody with two specificities is further fused to the Fc domain to form BsAb with 2+2 antigen-binding valency. This BsAb can bind two antigens simultaneously and block the synthesis of thyroid hormones. It is designed for the research of Autoimmune thyroid disease therapy.

Specifications
Targets
TG & TPO
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
TG
Host Animal 1
Mouse
Target 2
TPO
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Autoimmune thyroid disease
Targets
Target 1
TG
Gene ID
UniProt ID
Alternative Names
AITD3, TG; thyroglobulin; TGN
Target 2
TPO
Gene ID
UniProt ID
Alternative Names
MSA; TPX; TDH2A; TPPO; thrombopoietin; megakaryocyte growth and development factor; MGDF
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