Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scFv-CH3) (BSFC-189)

Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scFv-CH3) contains two chains. The anti-TG scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-TPO scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind two antigens simultaneously and block the synthesis of thyroid hormones. It is designed for the research of Autoimmune thyroid disease therapy.

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Specifications

Targets

TG & TPO

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Autoimmune thyroid disease

Targets

Target 1

Gene ID

7038

UniProt ID

P01266

Alternative Names

AITD3, TG; thyroglobulin; TGN

Target 2

TPO

Gene ID

7173

UniProt ID

P07202

Alternative Names

MSA; TPX; TDH2A; TPPO; thrombopoietin; megakaryocyte growth and development factor; MGDF

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scFv-CH3) (CAT#: BSFC-189)

Specifications

Targets

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