Home > Products > TG & TPO > Recombinant Human Anti-TG x Human Anti-TPO Bispecific Antibody (scFv4-Ig)

Recombinant Human Anti-TG x Human Anti-TPO Bispecific Antibody (scFv4-Ig)  (FVTIG-H351)

Recombinant Anti-TG x Anti-TPO Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-TG scFv is fused to the CH1 domain of a heavy chain and another anti-TPO scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two antigens simultaneously and block the synthesis of thyroid hormones. It is designed for the research of Autoimmune thyroid disease therapy.

Specifications
Targets
TG & TPO
Type
Appended IgGs
Species Reactivity
Human
Target 1
TG
Host Animal 1
Human
Target 2
TPO
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Autoimmune thyroid disease
Targets
Target 1
TG
Gene ID
UniProt ID
Alternative Names
AITD3, TG; thyroglobulin; TGN
Target 2
TPO
Gene ID
UniProt ID
Alternative Names
MSA; TPX; TDH2A; TPPO; thrombopoietin; megakaryocyte growth and development factor; MGDF
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