Recombinant Human Anti-TPBG x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H175)

Recombinant Anti-TPBG x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) is designed to be expressed as a single chain with three scFv units, two distal binding sites for TPBG and a central site for CD3. It contains a His-tag at the C/N terminus for affinity purification. This BsAb can retarget T cells to tumor cells. It is designed for the research of Renal cell cancer (RCC); Non-small lung cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & TPBG

Type

Single-chain Triplebody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Renal cell cancer (RCC); Non-small lung cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

TPBG

Gene ID

7162

UniProt ID

Q13641

Alternative Names

5T4; M6P1; 5T4AG; WAIF1; trophoblast glycoprotein; TPBG

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-TPBG x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (CAT#: SCTB-H175)

Specifications

Targets

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