Recombinant Human Anti-TROP2 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H176)

Recombinant Anti-TROP2 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) is designed to be expressed as a single chain with three scFv units, two distal binding sites for TROP2 and a central site for CD3. It contains a His-tag at the C/N terminus for affinity purification. This BsAb can retarget T cells to tumor cells. It is designed for the research of Pancreatic cancer; Breast cancer; Gastrointestinal cancer; Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & TROP2

Type

Single-chain Triplebody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic cancer; Breast cancer; Gastrointestinal cancer; Cancers

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

TROP2

Gene ID

4070

UniProt ID

P09758

Alternative Names

TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; Trop-2; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Human Anti-TROP2 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H176). Click the button below to contact us or submit your feedback about this product.

Recombinant Human Anti-TROP2 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (CAT#: SCTB-H176)

Specifications

Targets

Customer Reviews and Q&As