Home > Products > VEGFB & VEGF > Recombinant Human Anti-VEGFB x Human Anti-VEGF Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-VEGFB x Human Anti-VEGF Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H352)

Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-VEGFB antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGF to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block two proangiogenics simultaneously. It is designed for the research of Cancers therapy.

Specifications
Targets
VEGFB & VEGF
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
VEGFB
Host Animal 1
Human
Target 2
VEGF
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers
Targets
Target 1
VEGFB
Gene ID
UniProt ID
Alternative Names
VRF; VEGFL; VEGFB; vascular endothelial growth factor B
Target 2
VEGF
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
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