Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-VEGFB antibody are fused to the C terminus of an anti-VEGF IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can block two proangiogenics simultaneously. It is designed for the research of Cancers therapy.