Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-VEGFB antibody variable domain is linked to another scFv of an anti-VEGF antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can block two proangiogenics simultaneously. It is designed for the research of Cancers therapy.