Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (scFv-CH3) contains two chains. The anti-VEGFB scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-VEGF scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can block two proangiogenics simultaneously. It is designed for the research of Cancers therapy.