Home > Products > CD3 & VEGFR1 > Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody)

Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody)  (SCTB-H177)

Recombinant Anti-VEGFR1 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) is designed to be expressed as a single chain with three scFv units, two distal binding sites for VEGFR1 and a central site for CD3. It contains a His-tag at the C/N terminus for affinity purification. This BsAb can retarget T cells to tumor cells. It is designed for the research of Colon cancer; Rectal cancer therapy.

Specifications

Targets
CD3 & VEGFR1
Type
Single-chain Triplebody
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
VEGFR1
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colon cancer; Rectal cancer

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.
Target 2
VEGFR1
Gene ID
UniProt ID
Alternative Names
FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H177). Click the button below to contact us or submit your feedback about this product.

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Welcome! For price inquiries, we will get back to you as soon as possible.

To order, please email

INQUIRY
Related products of "CD3 & VEGFR1"
Online Inquiry

24x7 Service quality
USA

Tel:
Fax:
Email:

UK

Tel:
Email:

Germany

Tel:
Email: