BsAb Design
BsAbs are artificially designed molecules, which enable to simultaneously recognize two or more different antigens. At the early stage of BsAb development, Creative Biolabs offers customized BsAb design services either for scientific research or clinical practice. More than that, we can provide a full range of BsAbs to meet every customer's requirement.
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Target Based BsAb Design (Creative Biolabs Authorized)
Bispecific antibodies (BsAbs) are capable of interfering with two (or more) targets (epitopes, ligands, receptors, or immune cells) simultaneously. Creative Biolabs is a global leader in the rapidly emerging market for BsAbs and is experienced in Target based BsAb design.
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In leveraging the body's immune arsenal, Creative Biolabs has developed advanced BsAb platforms to revolutionize cancer immunotherapy. These engineered BsAbs simultaneously bind distinct receptors, thereby linking immune cells with tumor-associated antigens. This dual targeting elicits immune cell activation, cytokine secretion, phagocytosis, and antibody-dependent cytotoxicity, collectively facilitating tumor eradication.
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Immune Cell Engager Based BsAb Design (Creative Biolabs Authorized)
BsAbs for Signaling Interference (Creative Biolabs Authorized)
Our state‐of‐the‐art BsAb platform facilitates the development of agents that interfere with aberrant signaling pathways implicated in cancer progression. By simultaneously targeting receptor activation, proangiogenic factors, or proinflammatory cytokines, these BsAbs disrupt malignant cell proliferation via dual blockade of ligand–receptor interactions. Together, our extensive expertise and innovative technologies underscore our commitment to advancing targeted disease therapies.
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BsAbs, with dual antigen-binding sites, effectively juxtapose distinct proteins within a complex, facilitating requisite protein-protein interactions essential for signal transduction. Creative Biolabs is a pioneering global enterprise in BsAb engineering, adept at fabricating novel agents such as KIH BsAbs for enforced protein assembly. Our comprehensive antibody design platforms ensure diverse BsAb constructs customized to drive forced protein associations with remarkable clinical impact.
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BsAbs for Protein Mimetic (Creative Biolabs Authorized)
BsAbs for Pretargeting System (Creative Biolabs Authorized)
In payload delivery, BsAbs enable precise routing of drugs, radiolabels, or small molecules, enhancing imaging specificity and therapeutic efficacy in oncology. The innovative pretargeting approach utilizes BsAbs to localize tumors followed by subsequent radionuclide administration, minimizing off-target toxicity while obviating blood‐clearing agents due to rapid BsAb clearance. Creative Biolabs offer bespoke BsAb design Service, ensuring high fidelity products.
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Creative Biolabs harnesses advanced computational modeling and artificial intelligence to revolutionize BsAb design. Recognizing the inherent complexity of these molecules, we integrate traditional antibody engineering techniques with in silico approaches to enhance safety, efficacy, and manufacturability. With support from high-throughput contract research organizations skilled in testing intricate BsAbs, Creative Biolabs expedites the discovery and advancement of multifaceted therapeutics. The novel methodologies and recent technological breakthroughs underscore the promising future of bispecific modalities, ensuring that innovative bispecific therapeutics overcome design challenges and rapidly transition from concept to clinical reality.
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AI-based BsAb Optimization (Creative Biolabs Authorized)
Parent Antibody High-Throughput Screening (Creative Biolabs Authorized)
BsAbs, an emergent immunotherapy class impaired by inefficient discovery processes that restrict widespread clinical use. Creative Biolabs deploys a state‐of‐the-art, high‐throughput screening platform incorporating phage display, yeast display, and rapid expression methodologies to robustly identify parent antibodies. Our innovative approach dramatically accelerates the immunotherapeutic pipeline, enabling the rapid generation of superior, cost‐effective BsAbs. By streamlining discovery, we aim to expand the clinical availability of these transformative agents, thereby enhancing therapeutic options across diverse disease indications and advancing the frontiers of immunotherapy remarkably.
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Focus on Bispecific Antibody, Focus on Creative Biolabs

Novel Platforms Facilitate Innovative and Efficient BsAb Development