Cardiology

Introduction of Cardiology

The discipline of cardiology encompasses the comprehensive study of the heart and cardiovascular system, addressing various disorders and conditions. This medical discipline encompasses the diagnosis and management of various cardiovascular conditions, spanning from coronary artery disease and electrophysiology to heart failure. With a growing recognition of the escalating burden of cardiovascular diseases, particularly in younger populations, there is an increasing emphasis on preventive cardiology. According to the World Health Organization (WHO), a substantial proportion of premature deaths worldwide result from cardiovascular diseases, with a significant majority occurring in low and middle-income countries.

BsAbs in Cardiology

Bispecific antibodies (BsAbs) emerge as promising candidates for addressing cardiovascular ailments. Various strategies have been devised to target the heart, harnessing the innate binding specificity of antibodies. BsAbs are engineered to bind two distinct targets concurrently, combining variable domains of specific monoclonal antibodies into an integrated structure. They are crafted through chemical conjugation, hybridoma fusion, or genetic engineering like recombinant DNA technology. In a recent study, BsAbs are designed to link F(ab')2 fragments targeting CD34 and anti-cardiac myosin heavy chain, redirecting bone marrow stem cells (BMSCs) to injured hearts. Similarly, an inhalable platelet-targeting bispecific antibody (PT-BsAb) has been developed, connecting CD34 and CD42b, to guide stem cells from lungs to heart for repair post-injury, showcasing promising therapeutic potential in cardiac regeneration.

Creative Biolabs offers over 100 kinds of BsAbs to help the research of cardiology therapy, customization options are available to tailor cardiovascular ailments bispecific antibodies to suit specific requirements.

Fig. 1 Illustration of cardiac circulation.¹

Reference

1. From Wikipedia: By ZooFari - Own work, CC BY-SA 3.0,
https://commons.wikimedia.org/wiki/File:Heart_diagram_blood_flow_en.svg.